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Hubbard SR, et al.  (1994) Crystal structure of the tyrosine kinase domain of the human insulin receptor. Nature 372(6508):746-54

Abstract: The X-ray crystal structure of the tyrosine kinase domain of the human insulin receptor has been determined by multiwavelength anomalous diffraction phasing and refined to 2.1 A resolution. The structure reveals the determinants of substrate preference for tyrosine rather than serine or threonine and a novel autoinhibition mechanism whereby one of the tyrosines that is autophosphorylated in response to insulin, Tyr 1,162, is bound in the active site.AD - Department of Biochemistry and MolecularBiophysics, Columbia University, New York, New York 10032.FAU - Hubbard, S .

Status: Published

Type: Journal Article

PubMed ID: 7997262

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Hubbard SR Wei L Ellis L Hendrickson WA Papers in SGD Colleagues in SGD PubMed Google Scholar

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