Savva R, et al. (1995) The structural basis of specific base-excision repair by uracil-DNA glycosylase. Nature 373(6514):487-93
Abstract: The 1.75-A crystal structure of the uracil-DNA glycosylase from herpes simplex virus type-1 reveals a new fold, distantly related to dinucleotide-binding proteins. Complexes with a trideoxynucleotide, and with uracil, define the DNA-binding site and allow a detailed understanding of the exquisitely specific recognition of uracil in DNA. The overall structure suggests binding models for elongated single- and double-stranded DNA substrates. Conserved residues close to the uracil-binding site suggest a catalytic mechanism for hydrolytic base excision.
|Status: Published||Type: Journal Article||PubMed ID: 7845459|