Finn BE, et al. (1995) Calcium-induced structural changes and domain autonomy in calmodulin. Nat Struct Biol 2(9):777-83
Abstract: We have determined the solution structures of the apo and (Ca2+)2 forms of the carboxy-terminal domain of calmodulin using multidimensional heteronuclear nuclear magnetic resonance spectroscopy. The results show that both forms adopt well-defined structures with essentially equal secondary structure. A comparison of the structures of the two forms shows that Ca2+ binding causes major rearrangements of the secondary structure elements with changes in inter-residue distances of up to 15 A and exposure of the hydrophobic interior of the four-helix bundle. Comparisons with previously determined high-resolution X-ray structures and models of calmodulin indicate that this domain is structurally autonomous.AD -Department of Physical Chemistry, Lund University, Sweden.FAU - Finn, B .
|Status: Published||Type: Journal Article||PubMed ID: 7552749|