Nazarko VY and Zhong Q (2013) ULK1 targets Beclin-1 in autophagy. Nat Cell Biol 15(7):727-8
Abstract: The substrates of mammalian ULK1/2 and its yeast homologue Atg1 in autophagy have remained elusive. The class III phosphatidylinositol 3-kinase component Beclin-1 has now been identified as a physiological substrate of the ULK kinases in autophagy following amino acid starvation, therefore suggesting a critical molecular link between the upstream kinases and the autophagy core machinery.
|Status: Published||Type: Journal Article||PubMed ID: 23817237|
Topics addressed in this paper
Number of different genes curated to this paper: 6
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