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Sun S and Cleveland DW (2012) TDP-43 toxicity and the usefulness of junk. Nat Genet 44(12):1289-91
Abstract: A new study shows that loss of the lariat debranching enzyme Dbr1 suppresses TDP-43 toxicity. The accumulated intronic lariat RNAs, which are normally degraded after splicing, likely act as decoys to sequester TDP-43 away from binding to and disrupting functions of other RNAs.
| Status: Published | Type: Journal Article | PubMed ID: 23192178 |
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