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van Werven FJ, et al.  (2012) Transcription of two long noncoding RNAs mediates mating-type control of gametogenesis in budding yeast. Cell 150(6):1170-81

Abstract: The cell-fate decision leading to gametogenesis is essential for sexual reproduction. In S. cerevisiae, only diploid MATa/a but not haploid MATa or MATa cells undergo gametogenesis, known as sporulation. We find that transcription of two long noncoding RNAs (lncRNAs) mediates mating-type control of sporulation. In MATa or MATa haploids, expression of IME1, the central inducer of gametogenesis, is inhibited in cis by transcription of the lncRNA IRT1, located in the IME1 promoter. IRT1 transcription recruits the Set2 histone methyltransferase and the Set3 histone deacetylase complex to establish repressive chromatin at the IME1 promoter. Inhibiting expression of IRT1 and an antisense transcript that antagonizes the expression of the meiotic regulator IME4 allows cells expressing the haploid mating type to sporulate with kinetics that are indistinguishable from that of MATa/a diploids. Conversely, expression of the two lncRNAs abolishes sporulation in MATa/a diploids. Thus, transcription of two lncRNAs governs mating-type control of gametogenesis in yeast.

Status: Published Type: Journal Article PubMed ID: 22959267

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HHT1 HHT2 HOS2 IME1 POG1 RME1 RME2 SET2 SET3
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