Ira G and Hastings PJ (2012) DNA breakage drives nuclear search. Nat Cell Biol 14(5):448-50
Abstract: The search for a homologous template is a fundamental, yet largely uncharacterized, reaction in DNA double-strand break repair. Two reports now demonstrate that broken chromosomes increase their movement and explore large volumes of nuclear space searching for a homologous template. Break mobility requires resection and recombination enzymes, as well as damage-checkpoint components.
|Status: Published||Type: Comment | Journal Article||PubMed ID: 22552144|
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