Song W and Petes TD (2012) Haploidization in Saccharomyces cerevisiae induced by a deficiency in homologous recombination. Genetics 191(1):279-84
Abstract: Diploid Saccharomyes cerevisae strains lacking the RAD52 gene required for homologous recombination have a very high rate of chromosome loss. Two of four isolates subcultured ~20 times (~500 cell divisions) became haploid. These strains were capable of mating with wild-type haploids to produce diploid progeny capable of undergoing meiosis to produce four viable spores.
|Status: Published||Type: Journal Article | Research Support, N.I.H., Extramural||PubMed ID: 22367034|
Topics addressed in this paper
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