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Kuryan BG, et al.  (2012) Histone density is maintained during transcription mediated by the chromatin remodeler RSC and histone chaperone NAP1 in vitro. Proc Natl Acad Sci U S A 109(6):1931-6

Abstract: ATPases and histone chaperones facilitate RNA polymerase II (pol II) elongation on chromatin. In vivo, the coordinated action of these enzymes is necessary to permit pol II passage through a nucleosome while restoring histone density afterward. We have developed a biochemical system recapitulating this basic process. Transcription through a nucleosome in vitro requires the ATPase remodels structure of chromatin (RSC) and the histone chaperone nucleosome assembly protein 1 (NAP1). In the presence of NAP1, RSC generates a hexasome. Despite the propensity of RSC to evict histones, NAP1 reprograms the reaction such that the hexasome is retained on the template during multiple rounds of transcription. This work has implications toward understanding the mechanism of pol II elongation on chromatin.

Status: Published Type: Journal Article | Research Support, N.I.H., Extramural PubMed ID: 22308335

Topics addressed in this paper

Number of different genes curated to this paper: 48

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Topics Genes linked to topics (#1 - 10 )
ARP7 ARP9 ASF1 HHT1 HHT2 HTA1 HTA2 HTL1 LDB7 NAP1
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Topics Genes linked to topics (#11 - 20 )
NHP6A NPL6 POB3 RPB10 RPB11 RPB2 RPB3 RPB4 RPB5 RPB7
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Topics Genes linked to topics (#21 - 30 )
RPB8 RPB9 RPC10 RPO21 RPO26 RSC1 RSC2 RSC3 RSC30 RSC4
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Topics Genes linked to topics (#31 - 40 )
RSC58 RSC6 RSC8 RSC9 RTT102 SFH1 SNF11 SNF12 SNF2 SNF5
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Topics Genes linked to topics (#41 - 48 )
SNF6 SPT16 SPT6 STH1 SWI1 SWI3 SWP82 TAF14
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