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Inoue T, et al.  (2012) Characterization and isolation of mutants producing increased amounts of isoamyl acetate derived from hygromycin B-resistant sake yeast. Biosci Biotechnol Biochem 76(1):60-6

Abstract: Hygromycin B is an aminoglycoside antibiotic that inhibits protein synthesis in prokaryotes and eukaryotes. Twenty-four hygromycin B-resistants mutants were isolated from sake yeast, and were divided into three different degrees of strength according to hygromycin B resistance. Three of four hygromycin B strongly resistant mutants produced increased amounts of isoamyl acetate in sake brewing test, although isoamyl alcohol levels remained unchanged. Many hygromycin B-resistants mutants showed higher E/A ratios than K-701 in culture with koji extract medium. Strain HMR-18 produced the largest amount of isoamyl acetate, and its alcohol acetyltransferase (AATFase) activity was 1.3-fold that of K-701. DNA microarray analysis showed that many genes overexpressed in HMR-18 were involved in stress responses (heat shock, low pH, and so on) but HMR-18 showed thermo- and acid-sensitivity. It was strongly resistant to hygromycin B and another aminoglycoside antibiotic, G418.

Status: Published Type: Journal Article PubMed ID: 22232249

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ARG1 CAR1 CAR2 CIS3 CUP1-1 CUP1-2 CYB5 DIP5 GUT2 HSP150
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IMP2' LEU1 NQM1 PIR1 PIR3 PST1 RPI1 SEC28 SED1 SNZ3
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SUC2 SVS1 THI74 TIP1 YOL159C YPS6
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