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Vizoso-Vazquez A, et al.  (2012) Ixr1p and the control of the Saccharomyces cerevisiae hypoxic response. Appl Microbiol Biotechnol 94(1):173-84

Abstract: In Saccharomyces cerevisiae, adaptation to hypoxia/anaerobiosis requires the transcriptional induction or derepression of multiple genes organized in regulons controlled by specific transcriptional regulators. Ixr1p is a transcriptional regulatory factor that causes aerobic repression of several hypoxic genes (COX5B, TIR1, and HEM13) and also the activation of HEM13 during hypoxic growth. Analysis of the transcriptome of the wild-type strain BY4741 and its isogenic derivative ?ixr1, grown in aerobic and hypoxic conditions, reveals differential regulation of genes related not only to the hypoxic and oxidative stress responses but also to the re-adaptation of catabolic and anabolic fluxes in response to oxygen limitation. The function of Ixr1p in the transcriptional regulation of genes from the sulfate assimilation pathway and other pathways producing a-keto acids is of biotechnological importance for industries based on yeast-derived fermentation products.

Status: Published Type: Journal Article PubMed ID: 22189861

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AAC1 AAD3 ABF2 ACB1 ACH1 ACK1 ADE3 ADE5,7 ADH2 ADH3
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ADH5 ADI1 ADO1 AGP2 ALD3 ALD4 ALG6 ALR1 AMD2 AME1
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ANP1 APE3 AQR1 ARG1 ARG80 ARG81 ARN2 ARO8 ASR1 ATF1
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Topics Genes linked to topics (#31 - 40 )
AVT1 AXL1 AYT1 AZR1 BAP3 BAT1 BAT2 BUB1 CBK1 CCR4
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CDC19 CDC28 CDC48 CDC8 CLA4 CLB5 CNA1 COX9 CTT1 CWP1
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DAK1 DAL81 DAN1 DBP7 DDR2 DIC1 DIP5 DSE2 DUR3 ECM10
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Topics Genes linked to topics (#61 - 70 )
EGD1 ERC1 ERG11 ERG4 ERR1 EST3 FET4 FIT1 FIT3 FLR1
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Topics Genes linked to topics (#71 - 80 )
FMP46 FRD1 FZF1 GAL11 GCY1 GDH1 GDH3 GLC3 GLK1 GLO4
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Topics Genes linked to topics (#81 - 90 )
GNA1 GPD2 GPM1 GPX2 GRE1 GRX1 GRX2 GSF2 GSY1 GSY2
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Topics Genes linked to topics (#91 - 100 )
GTT1 HAP2 HEF3 HEM3 HEM4 HES1 HIP1 HIS4 HNT2 HOG1
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Topics Genes linked to topics (#101 - 110 )
HOR7 HPF1 HSP12 HSP150 HSP78 HXK1 HXT1 HXT2 HXT4 HXT5
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Topics Genes linked to topics (#111 - 120 )
HXT7 HYR1 ILV2 ILV3 ILV5 ILV6 IMD2 IMD3 IMD4 IPL1
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Topics Genes linked to topics (#121 - 130 )
IRC7 ITR2 IXR1 KGD1 KKQ8 KTR4 LAG1 LAG2 LCB4 LEU1
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Topics Genes linked to topics (#131 - 140 )
LEU4 LEU9 LPD1 LYP1 MAL31 MAM3 MCM1 MEP2 MET1 MET10
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Topics Genes linked to topics (#141 - 150 )
MET14 MET16 MET3 MET32 MET5 MIG1 MIR1 MKS1 MOT3 MPH2
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Topics Genes linked to topics (#151 - 160 )
MPT5 MSC1 MSS18 MXR1 NAM7 NIT1 NIT2 NPR1 NPY1 NRT1
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Topics Genes linked to topics (#161 - 170 )
NSR1 OAC1 ODC1 OLE1 PAI3 PAM1 PAU2 PAU21 PBI2 PDC5
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PDI1 PFK2 PHB2 PIR1 PIR3 PKP1 PKP2 POP2 PRR1 PRS3
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PSA1 PSR1 PSR2 PTC6 PTP3 PUS5 QDR2 QDR3 RAS2 RGT1
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RIM101 RIM11 ROG3 RPT1 RRG9 RSP5 RTS3 SAM1 SAM2 SAM3
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SAP1 SED1 SIW14 SKN7 SLN1 SNF1 SNF5 SNG1 SPI1 SPO12
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SSB2 SSD1 SSE2 SSU72 STF2 STR3 SVS1 TDH1 TDH2 TDH3
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Topics Genes linked to topics (#221 - 230 )
TFS1 THI5 THI80 TIP1 TIR1 TIR3 TIR4 TPO1 TPO2 TPO4
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Topics Genes linked to topics (#231 - 240 )
TPS2 TRE2 TRR2 TRX2 TSA2 TSL1 UBA1 UBI4 UBP2 UGP1
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Topics Genes linked to topics (#241 - 250 )
URA10 UTH1 VHS1 VID30 VPH1 VTC2 XKS1 YAK1 YAT2 YBR016W
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Topics Genes linked to topics (#251 - 260 )
YBR241C YBR284W YCK2 YFL052W YGL177W YGP1 YHR138C YJR096W YMR31 YNL234W
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Topics Genes linked to topics (#261 - 263 )
YOR097C YUH1 ZDS1
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