SGD Paper 
Slavov N, et al. (2011) Metabolic cycling without cell division cycling in respiring yeast. Proc Natl Acad Sci U S A 108(47):19090-5
Abstract: Despite rapid progress in characterizing the yeast metabolic cycle, its connection to the cell division cycle (CDC) has remained unclear. We discovered that a prototrophic batch culture of budding yeast, growing in a phosphate-limited ethanol medium, synchronizes spontaneously and goes through multiple metabolic cycles, whereas the fraction of cells in the G1/G0 phase of the CDC increases monotonically from 90 to 99%. This demonstrates that metabolic cycling does not require cell division cycling and that metabolic synchrony does not require carbon-source limitation. More than 3,000 genes, including most genes annotated to the CDC, were expressed periodically in our batch culture, albeit a mere 10% of the cells divided asynchronously; only a smaller subset of CDC genes correlated with cell division. These results suggest that the yeast metabolic cycle reflects a growth cycle during G1/G0 and explains our previous puzzling observation that genes annotated to the CDC increase in expression at slow growth.
| Status: Published | Type: Journal Article | PubMed ID: 22065748 |
Topics addressed in this paper
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| Topics | Topics not linked to Genes |
|---|---|
| Cell Growth and Metabolism | 
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| Genomic expression study |
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| Omics |
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