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Latham JA, et al.  (2011) Chromatin Signaling to Kinetochores: Transregulation of Dam1 Methylation by Histone H2B Ubiquitination. Cell 146(5):709-19

Abstract: Histone H3K4 trimethylation by the Set1/MLL family of proteins provides a hallmark for transcriptional activity from yeast to humans. In S. cerevisiae, H3K4 methylation is mediated by the Set1-containing COMPASS complex and is regulated in trans by prior ubiquitination of histone H2BK123. All of the events that regulate H2BK123ub and H3K4me are thought to occur at gene promoters. Here we report that this pathway is indispensable for methylation of the only other known substrate of Set1, K233 in Dam1, at kinetochores. Deletion of RAD6, BRE1, or Paf1 complex members abolishes Dam1 methylation, as does mutation of H2BK123. Our results demonstrate that Set1-mediated methylation is regulated by a general pathway regardless of substrate that is composed of transcriptional regulatory factors functioning independently of transcription. Moreover, our data identify a node of regulatory crosstalk intrans between a histone modification and modification on a nonhistone protein, demonstrating that changing chromatin states can signal functional changes in other essential cellular proteins and machineries.CI - Copyright (c) 2011 Elsevier Inc. All rights reserved.

Status: Published Type: Journal Article PubMed ID: 21884933

Topics addressed in this paper

Number of different genes curated to this paper: 33

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Topics Genes linked to topics (#1 - 10 )
BRE1 BRE2 CBF2 CSE1 CTR9 DAM1 DOT1 HHT1 HHT2 HTA1
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Topics Genes linked to topics (#11 - 20 )
HTA2 HTB1 HTB2 IPL1 KIN28 PAF1 RAD18 RAD6 RKM4 RTF1
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Topics Genes linked to topics (#21 - 30 )
SDC1 SET1 SET2 SET3 SET4 SET5 SET6 SPP1 SWD1 TID3
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Topics Genes linked to topics (#31 - 33 )
UBP10 UBP8 UBR1
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