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Panek AC, et al. (1990) Regulation of trehalose metabolism in Saccharomyces cerevisiae mutants during temperature shifts. Biochimie 72(1):77-9
Abstract: Temperature shifts from 23 degrees C to 36 degrees C resulted in trehalose accumulation in Saccharomyces independently of genetic lesions in the cAMP-protein kinase cascade. In parallel, trehalose 6-phosphate synthase activity increased about 3-fold in all strains; the increase could be inhibited by cycloheximide, suggesting that protein synthesis was required. Heat shock treatment after the temperature shift led to a drastic increase in trehalose activity, and deactivation of the biosynthetic enzyme with a consequent drop in trehalose. Up to now no definite correlation between acquisition of thermotolerance and trehalose accumulation has been made.
| Status: Published | Type: Journal Article | Research Support, Non-U.S. Gov't | PubMed ID: 2160289 |
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