Sharifpoor S, et al. (2011) A quantitative literature-curated gold standard for kinase-substrate pairs. Genome Biol 12(4):R39
Abstract: We describe the Yeast Kinase Interaction Database (KID, http://www.moseslab.csb.utoronto.ca/KID/), which contains high- and low-throughput data relevant to phosphorylation events. KID includes 6,225 low-throughput and 21,990 high-throughput interactions, from greater than 35,000 experiments. By quantitatively integrating these data, we identified 517 high-confidence kinase-substrate pairs that we consider a gold standard. We show that this gold standard can be used to assess published high-throughput datasets, suggesting that it will enable similar rigorous assessments in the future.
|Status: Published||Type: Journal Article | Research Support, Non-U.S. Gov't||PubMed ID: 21492431|
Topics addressed in this paper
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|Topics||Topics not linked to Genes|