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Power P, et al.  (2011) Sub-Telomeric core X and Y' Elements in S.cerevisiae Suppress Extreme Variations in Gene Silencing. PLoS One 6(3):e17523

Abstract: Telomere Position Effect (TPE) is governed by strong repression signals emitted by telomeres via the Sir2/3/4 Histone Deacetylase complex. These signals are then relayed by weak proto-silencers residing in the subtelomeric core X and Y' elements. Subtelomeres also contain Sub-Telomeric Anti-silencing Regions (STARs). In this study we have prepared telomeres built of different combinations of core X, Y' and STARs and have analyzed them in strains lacking Histone-Acetyltransferase genes as well as in cdc6-1 and Deltarif1 strains. We show that core X and Y' dramatically reduce both positive and negative variations in TPE, that are caused by these mutations. We also show that the deletion of Histone-Acetyltransferase genes reduce the silencing activity of an ACS proto-silencer, but also reduce the anti-silencing activity of a STAR. We postulate that core X and Y' act as epigenetic "cushioning" cis-elements.

Status: Published Type: Journal Article PubMed ID: 21437278

Topics addressed in this paper

Number of different genes curated to this paper: 64

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Topics Genes linked to topics (#1 - 10 )
CDC45 CDC6 CDC7 GCN5 HAT1 MCM5 ORC2 ORC5 RIF1 RTT109
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#11 - 20 )
SAS2 SAS3 TEL01L-XC TEL01R-XC TEL02L-XC TEL02L-YP TEL02R-XC TEL03L-XC TEL03R-XC TEL04L-XC
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball
Primary Literature blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 30 )
TEL04R-XC TEL04R-YP TEL05L-XC TEL05L-YP TEL05R-XC TEL05R-YP TEL06L-XC TEL06L-YP TEL06R-XC TEL07L-XC
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 40 )
TEL07R-XC TEL07R-YP TEL08L-XC TEL08L-YP TEL08R-XC TEL08R-YP TEL09L-XC TEL09L-YP TEL09R-XC TEL10L-XC
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Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#41 - 50 )
TEL10L-YP TEL10R-XC TEL11L-XC TEL11R-XC TEL12L-XC TEL12L-YP1 TEL12L-YP2 TEL12R-XC TEL12R-YP1 TEL12R-YP2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#51 - 60 )
TEL13L-XC TEL13L-YP TEL13R-XC TEL14L-XC TEL14L-YP TEL14R-XC TEL15L-XC TEL15R-XC TEL15R-YP TEL16L-XC
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#61 - 64 )
TEL16L-YP TEL16R-XC TEL16R-YP YNG1
Additional Literature blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball
Mutants/Phenotypes blue ball
Primary Literature blue ball
Strains/Constructs blue ball blue ball blue ball blue ball

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