Johnson B, et al. (2011) N(5)-Phosphonoacetyl-l-ornithine (PALO): A convenient synthesis and investigation of influence on regulation of amino acid biosynthetic genes in Saccharomyces cerevisiae. Bioorg Med Chem Lett 21(8):2351-3
Abstract: A scalable four-step synthesis of the ornithine transcarbamylase inhibitor N(5)-phosphonoacetyl-l-ornithine (PALO) is achieved through boroxazolidinone protection of ornithine. Investigations in the model organism Saccharomyces cerevisiae found that, in contrast to a previous report, PALO did not influence growth rate or expression of genes involved in arginine metabolism.CI - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
|Status: Published||Type: Journal Article||PubMed ID: 21421312|
Topics addressed in this paper
Number of different genes curated to this paper: 3
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