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Polo SE and Jackson SP  (2011) Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev 25(5):409-33

Abstract: Genome integrity is constantly monitored by sophisticated cellular networks, collectively termed the DNA damage response (DDR). A common feature of DDR proteins is their mobilization in response to genotoxic stress. Here, we outline how the development of various complementary methodologies has provided valuable insights into the spatiotemporal dynamics of DDR protein assembly/disassembly at sites of DNA strand breaks in eukaryotic cells. Considerable advances have also been made in understanding the underlying molecular mechanisms for these events, with post-translational modifications of DDR factors being shown to play prominent roles in controlling the formation of foci in response to DNA-damaging agents. We review these regulatory mechanisms and discuss their biological significance to the DDR.

Status: Published Type: Journal Article | Research Support, Non-U.S. Gov't | Review PubMed ID: 21363960

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ACT1 ARP4 ARP5 ARP6 ARP7 ARP8 ARP9 CHK1 DNA2 DNL4
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DPB11 EAF1 EAF3 EAF5 EAF6 EAF7 EPL1 ESA1 EXO1 GCN5
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Topics Genes linked to topics (#21 - 30 )
HAT1 HST1 HTL1 IES1 IES3 IES4 INO80 LCD1 LDB7 LIF1
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Topics Genes linked to topics (#31 - 40 )
MEC1 MRC1 MRE11 MUS81 NEJ1 NHP10 NPL6 POL30 RAD1 RAD10
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Topics Genes linked to topics (#41 - 50 )
RAD50 RAD51 RAD52 RAD53 RAD54 RAD55 RAD57 RAD9 RFA1 RFA2
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Topics Genes linked to topics (#51 - 60 )
RFA3 RMI1 RPD3 RSC1 RSC2 RSC3 RSC30 RSC4 RSC58 RSC6
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Topics Genes linked to topics (#61 - 70 )
RSC8 RSC9 RTT102 RVB1 RVB2 SAE2 SFH1 SGS1 SIR2 SLX1
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Topics Genes linked to topics (#71 - 80 )
SLX4 SNF11 SNF12 SNF2 SNF5 SNF6 SRS2 STH1 SWC3 SWC4
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Topics Genes linked to topics (#81 - 90 )
SWC5 SWC7 SWI1 SWI3 SWP82 SWR1 TAF14 TEL1 TOP3 TRA1
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Topics Genes linked to topics (#91 - 98 )
VPS71 VPS72 XRS2 YAF9 YEN1 YKU70 YKU80 YNG2
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