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Cocklin R, et al.  (2011) New insight into the role of the Cdc34 ubiquitin-conjugating enzyme in cell cycle regulation via Ace2 and Sic1. Genetics 187(3):701-15

Abstract: The Cdc34 ubiquitin-conjugating enzyme plays a central role in progression of the cell cycle. Through analysis of the phenotype of a mutant missing a highly conserved sequence motif within the catalytic domain of Cdc34, we discovered previously unrecognized levels of regulation of the Ace2 transcription factor and the cyclin-dependent protein kinase inhibitor Sic1. In cells carrying the Cdc34(tm) mutation, which alters the conserved sequence, the cyclin-dependent protein kinase inhibitor Sic1, an SCF(Cdc4) substrate, has a shorter half-life, while the cyclin Cln1, an SCF(Grr1) substrate, has a longer half-life than in wild-type cells. Expression of the SIC1 gene cluster, which is regulated by Swi5 and Ace2 transcription factors, is induced in CDC34(tm) cells. Levels of Swi5, Ace2, and the SCF(Grr1) targets Cln1 and Cln2 are elevated in Cdc34(tm) cells, and loss of Grr1 causes an increase in Ace2 levels. Sic1 levels are similar in CDC34(tm) ace2Delta and wild-type cells, explaining a paradoxical increase in the steady-state level of Sic1 protein despite its reduced half-life. A screen for mutations that interact with CDC34(tm) uncovered novel regulators of Sic1, including genes encoding the polyubiquitin chain receptors Rad23 and Rpn10.CI - (c) 2011 by the Genetics Society of Americ.

Status: Published Type: Journal Article | Research Support, U.S. Gov't, Non-P.H.S. PubMed ID: 21196523

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Topics Genes linked to topics (#1 - 10 )
ABZ1 ACE2 ADE12 AHC1 AIM17 AIM4 AIM44 AMN1 APJ1 ASH1
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Topics Genes linked to topics (#11 - 20 )
BAG7 BNI4 BTN2 CDC34 CDC6 CHS1 CHS5 CIK1 CKA2 CLN1
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Topics Genes linked to topics (#21 - 30 )
CLN2 CMK2 COQ6 COX17 CTK1 CTK2 CTK3 CTS1 CTT1 CUR1
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Topics Genes linked to topics (#31 - 40 )
CYK3 DAK2 DBF2 DFM1 DIA1 DOM34 DSE1 DSE2 DSE3 DSE4
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Topics Genes linked to topics (#41 - 50 )
DYN1 DYN2 EDC2 EGT2 FAA3 FCY21 FES1 FPR1 FSF1 GAS2
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Topics Genes linked to topics (#51 - 60 )
GCN1 GET2 GIM5 GRR1 GVP36 HAA1 HAL1 HCH1 HHT1 HO
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Topics Genes linked to topics (#61 - 70 )
HRK1 HSP104 HSP150 HSP30 HSP42 HSP78 IES2 IES5 IML2 KAR3
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Topics Genes linked to topics (#71 - 80 )
LAG2 LSB3 MBF1 MGA1 MIG3 MNN11 MRE11 MTC6 NCS2 NIS1
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Topics Genes linked to topics (#81 - 90 )
NRG2 NUP100 OPI10 OPI3 PCL2 PCL9 PDR16 PDR17 PDR18 PEX13
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Topics Genes linked to topics (#91 - 100 )
PGM3 PHD1 PHM8 PIB2 PIC2 PIL1 PIR1 PIR3 PNC1 PPZ2
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Topics Genes linked to topics (#101 - 110 )
PRB1 PRR1 PRY3 PST1 RAD16 RAD23 RAD30 RAD51 RAS2 RIM101
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Topics Genes linked to topics (#111 - 120 )
RIM13 RIM20 RIM8 RIM9 RME1 ROG3 RPL16B RPL29 RPL34A RPL34B
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Topics Genes linked to topics (#121 - 130 )
RPN10 RTR2 SCW11 SDS24 SEC22 SET6 SIC1 SIP1 SIS1 SLM4
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Topics Genes linked to topics (#131 - 140 )
SOK2 SOL4 SPH1 SPI1 STB1 STF2 STP4 SWA2 SWI5 TDA6
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Topics Genes linked to topics (#141 - 150 )
TEC1 TIF4631 TIP41 TIR1 TOS3 TPK2 TPK3 TPO2 TPO3 TPO4
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Topics Genes linked to topics (#151 - 160 )
UBP14 VAC8 VPS21 VPS45 YAF9 YAP6 YCL049C YDL038C YEL043W YER130C
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Topics Genes linked to topics (#161 - 170 )
YFL040W YGP1 YHL042W YIR035C YJL144W YLR297W YMR102C YMR181C YNL034W YNL046W
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Topics Genes linked to topics (#171 - 179 )
YNR014W YOL014W YOP1 YPC1 YPL247C YPR015C YPS3 YRO2 YUR1
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