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Gallego O, et al.  (2010) A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae. Mol Syst Biol 6():430

Abstract: Protein-metabolite networks are central to biological systems, but are incompletely understood. Here, we report a screen to catalog protein-lipid interactions in yeast. We used arrays of 56 metabolites to measure lipid-binding fingerprints of 172 proteins, including 91 with predicted lipid-binding domains. We identified 530 protein-lipid associations, the majority of which are novel. To show the data set's biological value, we studied further several novel interactions with sphingolipids, a class of conserved bioactive lipids with an elusive mode of action. Integration of live-cell imaging suggests new cellular targets for these molecules, including several with pleckstrin homology (PH) domains. Validated interactions with Slm1, a regulator of actin polarization, show that PH domains can have unexpected lipid-binding specificities and can act as coincidence sensors for both phosphatidylinositol phosphates and phosphorylated sphingolipids.

Status: Published Type: Journal Article PubMed ID: 21119626

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Number of different genes curated to this paper: 172

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Topics Genes linked to topics (#1 - 10 )
ACP1 ADH3 AGE1 ALD2 AMN1 APN1 ARC1 ASK10 ATG18 ATG20
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#11 - 20 )
ATG26 BEM1 BEM2 BEM3 BOI1 BOI2 BTS1 BUD2 BUD4 CAB3
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball
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Non-Fungal Related Genes/Proteins blue ball blue ball
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Topics Genes linked to topics (#21 - 30 )
CAF120 CBR1 CDC24 CDC33 CDC39 CLA4 CRD1 CSR1 CTK3 CYB2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 40 )
CYB5 DAP1 DCP1 DNM1 DPB4 DPL1 DYN1 ECM25 EGD2 ENT1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#41 - 50 )
ENT2 ENT4 ENT5 ERG10 ERG12 ERG13 ERG26 ERG27 ERG5 EXO84
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#51 - 60 )
FAR1 FAR11 FOB1 FOL3 FPR1 GCN2 GGA1 GGA2 GRH1 HEM3
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball blue ball blue ball blue ball
Protein Sequence Features blue ball blue ball blue ball
Substrates/Ligands/Cofactors blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#61 - 70 )
HER1 HFM1 HSE1 HXK1 IDI1 ILV2 IRA2 IRC21 KES1 LAS17
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball
Function/Process blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball
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Substrates/Ligands/Cofactors blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#71 - 80 )
LCB4 LCB5 LSB5 LSP1 LYS2 MCM4 MDR1 MET18 MET6 MET8
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball blue ball
Primary Literature blue ball blue ball
Protein Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball blue ball
Substrates/Ligands/Cofactors blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#81 - 90 )
MSS4 MST1 MVD1 MVP1 NAS2 NIC96 NRD1 NUM1 NUP2 NVJ2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball
Protein Physical Properties blue ball
Protein Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball
Substrates/Ligands/Cofactors blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#91 - 100 )
OLE1 OPY1 OSH3 OSH6 OSH7 PCF11 PDR16 PDR17 PEP7 PHO81
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball
Protein Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball blue ball
Substrates/Ligands/Cofactors blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#101 - 110 )
PHS1 PIB1 PKC1 PKH1 PKH2 PSD2 PSE1 PSP1 PSY2 ROM2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball
Protein Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Substrates/Ligands/Cofactors blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#111 - 120 )
RPF2 RTT103 RVS161 RVS167 SAS2 SCH9 SCS7 SEC14 SEC23 SEC63
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball blue ball blue ball
Function/Process blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball
Protein Physical Properties blue ball
Protein Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball blue ball blue ball
Substrates/Ligands/Cofactors blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#121 - 130 )
SFH5 SGD1 SKG3 SKM1 SLA1 SLA2 SLC1 SLM1 SLM2 SNT2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball blue ball
Function/Process blue ball
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Primary Literature blue ball blue ball blue ball
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Topics Genes linked to topics (#131 - 140 )
SNX4 SNX41 SPO14 SRP68 STB5 STE5 STR2 SUM1 SUR7 SWH1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Protein Physical Properties blue ball blue ball
Protein Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball
Substrates/Ligands/Cofactors blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#141 - 150 )
SYT1 TCB2 TCB3 TFB1 TFS1 TMS1 TSC10 TUS1 TWF1 VPS17
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball
Protein Physical Properties blue ball
Protein Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball blue ball
Substrates/Ligands/Cofactors blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#151 - 160 )
VPS27 WBP1 XRN1 YAP1801 YAP1802 YEL1 YFR006W YHC1 YHR131C YIL151C
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball
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Regulation of blue ball blue ball
Substrates/Ligands/Cofactors blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#161 - 170 )
YKL091C YKR078W YLR179C YNL144C YPK1 YPK2 YPL150W YPR097W YPR174C YPT35
Additional Literature blue ball blue ball blue ball blue ball
Cellular Location blue ball
Function/Process blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball
Protein Physical Properties blue ball
Protein Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball
Substrates/Ligands/Cofactors blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#171 - 172 )
YRB2 YSP1
Additional Literature blue ball
Cellular Location blue ball
Non-Fungal Related Genes/Proteins blue ball
Primary Literature blue ball
Protein Sequence Features blue ball blue ball
Regulation of blue ball
Substrates/Ligands/Cofactors blue ball blue ball

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