Chatenay-Lapointe M and Shadel GS (2010) Stressed-out mitochondria get MAD. Cell Metab 12(6):559-60
Abstract: Mechanisms maintaining mitochondrial integrity range from specific repair pathways to wholesale degradation of damaged organelles. A recent study in Molecular Cell (Heo et al., 2010) adds another mechanism to this mitochondrial homeostasis toolkit: mitochondria-associated protein degradation (MAD) that ultimately directs endoplasmic reticulum-associated protein degradation (ERAD) pathway components to oxidatively stressed mitochondria.CI - Copyright (c) 2010 Elsevier Inc. All rights reserved.
|Status: Published||Type: Comment | Journal Article||PubMed ID: 21109188|
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