SGD Paper 
Rossouw D, et al. (2010) Comparative transcriptomic and proteomic profiling of industrial wine yeast strains. Appl Environ Microbiol 76(12):3911-23
Abstract: The geno- and phenotypic diversity of commercial Saccharomyces cerevisiae wine yeast strains provides an opportunity to apply the system-wide approaches that are reasonably well established for laboratory strains to generate insight on the functioning of complex cellular networks in industrial environments. We have previously analysed the transcriptomes of five industrial wine yeast strains at three time points during alcoholic fermentation. Here, we extend the comparative approach to include an iTRAQ-based proteomic analysis of two of the previously analysed wine yeast strains at the same three time points during fermentation in synthetic wine must. The data show that differences in the transcriptomes of the two strains at a given time point rather accurately reflect differences in the corresponding proteomes independently of the GO category, providing strong support for the biological relevance of comparative transcriptomic data sets in yeast. In line with previous observations, the alignment proves less accurate when assessing intrastrain changes at different time points. In this case, differences between transcriptome and proteome appear strongly dependent on the GO category of the corresponding genes. The data in particular suggest that metabolic enzymes and the corresponding genes appear strongly correlated over time and between strains, suggesting a strong transcriptional control of such enzymes. The data also allow the generation of hypotheses regarding the molecular origin of significant differences in phenotypic traits between the two strains.
| Status: Published | Type: Journal Article | PubMed ID: 20418425 |
Topics addressed in this paper
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| Topics | Topics not linked to Genes |
|---|---|
| Computational analysis | 
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| Genomic expression study |
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| Industrial Applications |
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| Large-scale protein detection |
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| Omics |
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