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Eisenberg T, et al.  (2009) Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 11(11):1305-14

Abstract: Ageing results from complex genetically and epigenetically programmed processes that are elicited in part by noxious or stressful events that cause programmed cell death. Here, we report that administration of spermidine, a natural polyamine whose intracellular concentration declines during human ageing, markedly extended the lifespan of yeast, flies and worms, and human immune cells. In addition, spermidine administration potently inhibited oxidative stress in ageing mice. In ageing yeast, spermidine treatment triggered epigenetic deacetylation of histone H3 through inhibition of histone acetyltransferases (HAT), suppressing oxidative stress and necrosis. Conversely, depletion of endogenous polyamines led to hyperacetylation, generation of reactive oxygen species, early necrotic death and decreased lifespan. The altered acetylation status of the chromatin led to significant upregulation of various autophagy-related transcripts, triggering autophagy in yeast, flies, worms and human cells. Finally, we found that enhanced autophagy is crucial for polyamine-induced suppression of necrosis and enhanced longevity.

Status: Published Type: Journal Article PubMed ID: 19801973

Topics addressed in this paper

Number of different genes curated to this paper: 37

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AHC1 ATG11 ATG15 ATG7 ATG8 ELP3 GCN5 HAT1 HDA1 HDA2
Additional Literature blue ball blue ball blue ball blue ball
Cell Growth and Metabolism yg ball
Cellular Location blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball
Other Features blue ball
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Topics Genes linked to topics (#11 - 20 )
HDA3 HHT1 HHT2 HOS1 HOS2 HOS3 HOS4 HPA2 HPA3 HST1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein Processing/Modification/Regulation blue ball blue ball
Protein Sequence Features blue ball blue ball
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Topics Genes linked to topics (#21 - 30 )
HST2 IKI3 NHP6A PHO23 RPD3 RXT2 SAP30 SAS3 SDS3 SET3
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Cellular Location blue ball
Genetic Interactions blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball
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Topics Genes linked to topics (#31 - 37 )
SGF73 SIF2 SIR2 SPE1 SPT10 VPS30 YNG1
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Alias blue ball
Genetic Interactions blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball
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