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van Werven FJ, et al.  (2009) Distinct promoter dynamics of the basal transcription factor TBP across the yeast genome. Nat Struct Mol Biol 16(10):1043-8

Abstract: Transcription regulation in eukaryotes involves rapid recruitment and proper assembly of transcription factors at gene promoters. To determine the dynamics of the transcription machinery on DNA, we used a differential chromatin immunoprecipitation procedure coupled to whole-genome microarray detection in Saccharomyces cerevisiae. We find that TATA-binding protein (TBP) turnover is low at RNA polymerase I (Pol I) promoters. Whereas RNA polymerase III (Pol III) promoters represent an intermediate case, TBP turnover is high at RNA polymerase II (Pol II) promoters. Within these promoters, the highest turnover correlates with binding of the Spt-Ada-Gcn5 acetyltransferase complex (SAGA) coactivator, Mot1p dependence and presence of a canonical TATA box. In contrast, slow turnover Pol II promoters depend on TFIID and on the gene-specific factor, Rap1p. Together this shows that TBP turnover is regulated by protein factors rather than DNA sequence and argues that TBP turnover is an important determinant in regulating gene expression.

Status: Published Type: Journal Article PubMed ID: 19767748

Topics addressed in this paper

Number of different genes curated to this paper: 41

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ADA2 BUR6 CHD1 GCN5 HFI1 HSF1 MOT1 NCB2 NGG1 PGK1
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DNA/RNA Sequence Features blue ball
Genomic co-immunoprecipitation study yg ball
Genomic expression study yg ball
Mutants/Phenotypes blue ball
Omics yg ball
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Protein-Nucleic Acid Interactions blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#11 - 20 )
RAP1 RPL28 SGF11 SGF29 SGF73 SKN7 SNR52 SNR6 SNR82 SPT15
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DNA/RNA Sequence Features blue ball blue ball blue ball blue ball
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Protein Physical Properties blue ball
Protein Processing/Modification/Regulation blue ball
Protein-Nucleic Acid Interactions blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#21 - 30 )
SPT20 SPT3 SPT7 SPT8 SUS1 TAF1 TAF10 TAF11 TAF12 TAF13
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-Nucleic Acid Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulatory Role blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 40 )
TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TRA1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-Nucleic Acid Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulatory Role blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#41 )
UBP8
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