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Zhang N, et al.  (2009) Gis1 is required for transcriptional reprogramming of carbon metabolism and the stress response during transition into stationary phase in yeast. Microbiology 155(Pt 5):1690-8

Abstract: Transition from growth to the stationary phase in yeast is still poorly understood. Previously, we identified a group of yeast genes that are universally up-regulated upon starvation for different macronutrients. Here, we demonstrate that the Gis1 transcription factor and the Rim15 kinase are responsible for the up-regulation of many of these genes. In chemostat cultures, gis1 or rim15 mutant cells are out-competed by their wild-type parents under conditions resembling the later stages of diauxie (glucose-limiting) and post-diauxie (ethanol as a carbon source). While Gis1p and Rim15p have distinct functions in gene repression, the growth defects of gis1 or rim15 deletants can be accounted for by the overlapping functions of their protein products in promoting the expression of genes involved in glutamate biosynthesis, the glyoxylate cycle, the pentose phosphate pathway, and the stress response. Further, we show that the sets of GIS1- and RIM15-dependent genes and the degree of their regulation change in response to the identity of the carbon source, suggesting the likely dynamics of gene regulation exerted by Rim15p and Gis1p during different phases of the transition into stationary phase. In particular, Rim15p is required for expression of genes involved in gluconeogenesis/glycolysis and glycerol biosynthesis only when ethanol is used as the carbon source. In agreement with this, Rim15p is shown to act in parallel with Hog1p to defend cells against osmotic stress.

Status: Published Type: Journal Article PubMed ID: 19383711

Topics addressed in this paper

Number of different genes curated to this paper: 66

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Topics Genes linked to topics (#1 - 10 )
AGX1 ATG8 BOP3 CTT1 DAL3 DAL5 DDR48 ERG28 FAA2 FBP1
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Topics Genes linked to topics (#11 - 20 )
FET4 FMP16 FRE3 GDH3 GIS1 GND2 GPD1 GPG1 GRE1 GSP2
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Topics Genes linked to topics (#21 - 30 )
HBT1 HOR2 HSP26 HXT5 ICL1 IDP2 JLP1 MLS1 MOH1 MSN4
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Topics Genes linked to topics (#31 - 40 )
PCK1 PGM2 PHM8 PIR3 PNS1 PRM5 PRR2 RGI2 RIM15 RTN2
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Topics Genes linked to topics (#41 - 50 )
SGA1 SIP18 SML1 SOL4 SPG1 SPG4 SSA3 TBF1 TKL2 TPK1
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Topics Genes linked to topics (#51 - 60 )
UGX2 UIP4 YCR061W YDL218W YGR066C YGR201C YHL044W YHR097C YHR140W YIL055C
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Topics Genes linked to topics (#61 - 66 )
YJL144W YJL163C YML131W YMR173W-A YMR181C YSC84
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DNA/RNA Sequence Features blue ball
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