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Harada Y, et al.  (2009) Oligosaccharyltransferase directly binds to ribosome at a location near the translocon-binding site. Proc Natl Acad Sci U S A 106(17):6945-9

Abstract: Oligosaccharyltransferase (OT) transfers high mannose-type glycans to the nascent polypeptides that are translated by the membrane-bound ribosome and translocated into the lumen of the endoplasmic reticulum through the Sec61 translocon complex. In this article, we show that purified ribosomes and OT can form a binary complex with a stoichiometry of approximately 1 to 1 in the presence of detergent. We present evidence that OT may bind to the large ribosomal subunit near the site where nascent polypeptides exit. We further show that OT and the Sec61 complex can simultaneously bind to ribosomes in vitro. Based on existing data and our findings, we propose that cotranslational translocation and N-glycosylation of nascent polypeptides are mediated by a ternary supramolecular complex consisting of OT, the Sec61 complex, and ribosomes.

Status: Published Type: Journal Article | Research Support, N.I.H., Extramural PubMed ID: 19365066

Topics addressed in this paper

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Topics Genes linked to topics (#1 - 10 )
NIP7 NMD3 OST1 OST2 OST3 OST4 OST5 OST6 RDN25-1 RDN25-2
Additional Literature blue ball blue ball blue ball blue ball
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Protein Physical Properties blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#11 - 20 )
RDN5-1 RDN5-2 RDN5-3 RDN5-4 RDN5-5 RDN5-6 RDN58-1 RDN58-2 RPL10 RPL11A
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-Nucleic Acid Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#21 - 30 )
RPL11B RPL12A RPL12B RPL13A RPL13B RPL14A RPL14B RPL15A RPL15B RPL16A
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Topics Genes linked to topics (#31 - 40 )
RPL16B RPL17A RPL17B RPL18A RPL18B RPL19A RPL19B RPL1A RPL1B RPL20A
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#41 - 50 )
RPL20B RPL21A RPL21B RPL22A RPL22B RPL23A RPL23B RPL24A RPL24B RPL25
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#51 - 60 )
RPL26A RPL26B RPL27A RPL27B RPL28 RPL29 RPL2A RPL2B RPL3 RPL30
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#61 - 70 )
RPL31A RPL31B RPL32 RPL33A RPL33B RPL34A RPL34B RPL35A RPL35B RPL36A
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Topics Genes linked to topics (#71 - 80 )
RPL36B RPL37A RPL37B RPL38 RPL39 RPL40A RPL40B RPL41A RPL41B RPL42A
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#81 - 90 )
RPL42B RPL43A RPL43B RPL4A RPL4B RPL5 RPL6A RPL6B RPL7A RPL7B
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#91 - 100 )
RPL8A RPL8B RPL9A RPL9B RPP0 RPP1A RPP1B RPP2A RPP2B SBH1
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Topics Genes linked to topics (#101 - 105 )
SEC61 SSS1 STT3 SWP1 WBP1
Additional Literature blue ball blue ball
Function/Process blue ball blue ball
Primary Literature blue ball blue ball blue ball
Protein Physical Properties blue ball blue ball blue ball
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