SGD Paper 
Mustonen V and Lassig M (2009) From fitness landscapes to seascapes: non-equilibrium dynamics of selection and adaptation. Trends Genet 25(3):111-9
Abstract: Evolution is a quest for innovation. Organisms adapt to changing natural selection by evolving new phenotypes. Can we read this dynamics in their genomes? Not every mutation under positive selection responds to a change in selection: beneficial changes also occur at evolutionary equilibrium, repairing previous deleterious changes and restoring existing functions. Adaptation, by contrast, is viewed here as a non-equilibrium phenomenon: the genomic response to time-dependent selection. Our approach extends the static concept of fitness landscapes to dynamic fitness seascapes. It shows that adaptation requires a surplus of beneficial substitutions over deleterious ones. Here, we focus on the evolution of yeast and Drosophila genomes, providing examples where adaptive evolution can and cannot be inferred, despite the presence of positive selection.
| Status: Published | Type: Journal Article | PubMed ID: 19232770 |
Topics addressed in this paper
- To find other papers on a gene and topic, click on the colored ball in the appropriate box.
- displays other papers with information about that topic for that gene.
- displays other papers in SGD that are associated with that topic.
The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
- To go to the Locus page for a gene, click on the gene name.
| Topics | Topics not linked to Genes |
|---|---|
| Evolution | 
|
