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Le Tallec B, et al.  (2009) Hsm3/S5b participates in the assembly pathway of the 19S regulatory particle of the proteasome. Mol Cell 33(3):389-99

Abstract: The 26S proteasome, the central enzyme of the ubiquitin-proteasome system, is comprised of the 20S catalytic core particle (CP) and the 19S regulatory particle (RP), itself composed of two subcomplexes, the base and the lid. 20S proteasome assembly is assisted by several chaperones. Integral subunits of the RP participate in its assembly, but no external factors have been identified so far. Here we characterize the yeast Hsm3 protein, which displays unique features regarding 19S assembly. Hsm3 associates with 19S subcomplexes via a carboxy-terminal domain of the Rpt1 base subunit but is missing in the final 26S proteasome. Moreover, Hsm3 is specifically required for the base subcomplex assembly. Finally, we identify the putative species-specific 19S subunit S5b as a functional homolog of the Hsm3 chaperone in mammals. These findings shed light on chaperone-assisted proteasome assembly in eukaryotes.

Status: Published Type: Journal Article | Research Support, Non-U.S. Gov't PubMed ID: 19217412

Topics addressed in this paper

Number of different genes curated to this paper: 23

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Topics Genes linked to topics (#1 - 10 )
BLM10 HSM3 PBA1 PRE2 PRE9 RAD53 RPN1 RPN10 RPN11 RPN12
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Topics Genes linked to topics (#11 - 20 )
RPN2 RPN4 RPN5 RPN6 RPN8 RPN9 RPT1 RPT2 RPT3 RPT5
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Topics Genes linked to topics (#21 - 23 )
RPT6 SCL1 SEM1
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Genetic Interactions blue ball blue ball
Mutants/Phenotypes blue ball blue ball
Primary Literature blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball

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