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Matsufuji Y, et al.  (2008) Acetaldehyde tolerance in Saccharomyces cerevisiae involves the pentose phosphate pathway and oleic acid biosynthesis. Yeast 25(11):825-33

Abstract: To identify genes responsible for acetaldehyde tolerance, genome-wide screening was performed using a collection of haploid Saccharomyces cerevisiae strains deleted in single genes. The screen identified 49 genes whose deletion conferred acetaldehyde sensitivity, and these were termed the genes required for acetaldehyde tolerance. We focused on six of these genes required for acetaldehyde tolerance, ZWF1, GND1, RPE1, TKL1 and TAL1, which encode enzymes in the pentose phosphate pathway (PPP), and OAR1, which encodes for NADPH-dependent 3-oxoacyl-(acyl-carrier-protein) reductase. These genes were not only responsible for acetaldehyde tolerance but also turned out to be induced by acetaldehyde. Moreover, the content of oleic acid was remarkably increased in yeast cells under acetaldehyde stress, and supplementation of oleic acid into the media partially alleviated acetaldehyde stress-induced growth inhibition of strains disrupted in the genes required for acetaldehyde tolerance and OLE1. Taken together, our data suggest that the supply of NADPH and the process of fatty acid biosynthesis are the key factors in acetaldehyde tolerance in the yeast, and that oleic acid plays an important role in acetaldehyde tolerance. Copyright (c) 2008 John Wiley & Sons, Ltd.

Status: Published Type: Journal Article PubMed ID: 19061187

Topics addressed in this paper

Number of different genes curated to this paper: 49

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ALD3 ALD6 AMD1 ARC1 ASC1 BEM4 BUD27 CIK1 COQ3 CSG2
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Topics Genes linked to topics (#11 - 20 )
ELP2 ELP3 GCR2 GND1 GSH1 HOM6 MSH1 OAR1 OLE1 PFK1
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Topics Genes linked to topics (#21 - 30 )
PRE9 RAD14 RHB1 RPE1 RPL43A RPN4 SHE4 SIN4 SKI8 SNF6
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Topics Genes linked to topics (#31 - 40 )
SRB2 SRB5 SSE1 STB5 TAL1 THR1 TKL1 UBA4 VMA1 VMA16
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Topics Genes linked to topics (#41 - 49 )
VMA21 VMA5 VMS1 VPS30 YDR048C YGL024W YGL214W YJL120W ZWF1
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