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Chaban Y, et al.  (2008) Structure of a RSC-nucleosome complex and insights into chromatin remodeling. Nat Struct Mol Biol 15(12):1272-7

Abstract: ATP-dependent chromatin-remodeling complexes, such as RSC, can reposition, evict or restructure nucleosomes. A structure of a RSC-nucleosome complex with a nucleosome determined by cryo-EM shows the nucleosome bound in a central RSC cavity. Extensive interaction of RSC with histones and DNA seems to destabilize the nucleosome and lead to an overall ATP-independent rearrangement of its structure. Nucleosomal DNA appears disordered and largely free to bulge out into solution as required for remodeling, but the structure of the RSC-nucleosome complex indicates that RSC is unlikely to displace the octamer from the nucleosome to which it is bound. Consideration of the RSC-nucleosome structure and published biochemical information suggests that ATP-dependent DNA translocation by RSC may result in the eviction of histone octamers from adjacent nucleosomes.

Status: Published Type: Journal Article PubMed ID: 19029894

Topics addressed in this paper

Number of different genes curated to this paper: 19

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Topics Genes linked to topics (#1 - 10 )
ARP7 ARP9 HTL1 LDB7 NPL6 RSC1 RSC2 RSC3 RSC30 RSC4
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein Physical Properties blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#11 - 19 )
RSC58 RSC6 RSC8 RSC9 RTT102 SFH1 SNF2 STH1 TAF14
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein Physical Properties blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein/Nucleic Acid Structure blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

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