Qi Y, et al. (2008) Finding friends and enemies in an enemies-only network: A graph diffusion kernel for predicting novel genetic interactions and co-complex membership from yeast genetic interactions. Genome Res 18(12):1991-2004
Abstract: The yeast synthetic lethal genetic interaction network contains rich information about underlying pathways and protein complexes as well as new genetic interactions yet to be discovered. We have developed a graph diffusion kernel as a unified framework for inferring complex/pathway membership analogous to "friends" and genetic interactions analogous to "enemies" from the genetic interaction network. When applied to the Saccharomyces cerevisiae genetic interaction network, we can achieve a precision around 50% with 20 to 50% recall in the genome-wide prediction of new genetic interactions, supported by experimental validation. The kernels show significant improvement over previous best methods for predicting genetic interactions and protein co-complex membership from genetic interaction data.
| Status: Published | Type: Journal Article | PubMed ID: 18832443 |
Topics addressed in this paper
Number of different genes curated to this paper: 184
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| Topics | Topics not linked to Genes | Genes linked to topics (#1 - 10 ) | |||||||||
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| AAH1 | ADA2 | AGE1 | AGE2 | AIM29 | ALG3 | ALG5 | ALG6 | ALG8 | ALG9 | ||
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| Topics | Genes linked to topics (#11 - 20 ) | |||||||||
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| ANP1 | ARL3 | ARP3 | ARP4 | ASK1 | BCY1 | BDF1 | BEM2 | BEM4 | BET2 | |
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| Topics | Genes linked to topics (#21 - 30 ) | |||||||||
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| BNI4 | BRE1 | BUB2 | BUR2 | BZZ1 | CAX4 | CBF2 | CDC20 | CDC28 | CDH1 | |
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| Topics | Genes linked to topics (#31 - 40 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CEP3 | CHS7 | CLA4 | CMD1 | COG4 | CSE2 | CSE4 | CTF13 | CTF3 | DBP10 | |
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| Topics | Genes linked to topics (#41 - 50 ) | |||||||||
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| DEP1 | DIE2 | DRS2 | DSL1 | DSS4 | EAF3 | EAF5 | EAF6 | EAF7 | ECM33 | |
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| Topics | Genes linked to topics (#51 - 60 ) | |||||||||
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| ECO1 | ELP2 | ELP3 | ELP4 | ELP6 | EPL1 | ESA1 | FET3 | FTR1 | GCN5 | |
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| Topics | Genes linked to topics (#61 - 70 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| GDI1 | GEA1 | GEA2 | GYP1 | HFI1 | HOF1 | HPR1 | HRT1 | HSC82 | HTZ1 | |
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| Topics | Genes linked to topics (#71 - 80 ) | |||||||||
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| IES3 | IKI3 | IRC3 | ISW1 | ISW2 | ITC1 | IXR1 | KIC1 | KIP2 | LGE1 | |
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| Topics | Genes linked to topics (#81 - 90 ) | |||||||||
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| MCM21 | MDM30 | MED1 | MED2 | MET22 | MIF2 | MND2 | MPS1 | MPS2 | MPS3 | |
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The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
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| Topics | Genes linked to topics (#91 - 100 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| MSB3 | MSI1 | MSO1 | MTC2 | MTW1 | NCS2 | NEO1 | NHP6B | NPL6 | NTO1 | |
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| Topics | Genes linked to topics (#101 - 110 ) | |||||||||
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| NUT1 | OST1 | OST5 | PAA1 | PAB1 | PAF1 | PEX32 | PHO2 | PHO23 | PKH1 | |
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| Topics | Genes linked to topics (#111 - 120 ) | |||||||||
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| PKH2 | PKR1 | PRB1 | PRE9 | RAD6 | RGD1 | RIC1 | RLF2 | RPD3 | RSC2 | |
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| Topics | Genes linked to topics (#121 - 130 ) | |||||||||
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| RTT109 | RUD3 | SAP30 | SAS3 | SDC1 | SDS3 | SEC2 | SEC4 | SEC9 | SFH1 | |
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| Topics | Genes linked to topics (#131 - 140 ) | |||||||||
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| SFI1 | SGF73 | SHR3 | SIC1 | SIN3 | SIN4 | SLY1 | SNF5 | SNT1 | SOH1 | |
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| Topics | Genes linked to topics (#141 - 150 ) | |||||||||
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| SPA2 | SPT20 | SPT3 | SPT7 | SPT8 | SRO7 | SSA1 | SSN2 | SSN3 | SSN8 | |
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| Topics | Genes linked to topics (#151 - 160 ) | |||||||||
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| STE14 | STE50 | STH1 | SWC4 | SWD1 | SWD3 | SWI4 | SWI6 | SWM1 | TEL1 | |
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| Topics | Genes linked to topics (#161 - 170 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| TIP20 | UBS1 | ULA1 | USO1 | VMA1 | VMA16 | VMA2 | VMA22 | VMA7 | VMA8 | |
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| Topics | Genes linked to topics (#171 - 180 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| VPH2 | WHI5 | YAF9 | YBL071C | YDL050C | YER156C | YKL118W | YKU80 | YNG1 | YNG2 | |
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| Topics | Genes linked to topics (#181 - 184 ) | |||
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| YOR331C | YPT11 | YTA12 | YTA7 | |
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