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Thompson DM, et al.  (2008) tRNA cleavage is a conserved response to oxidative stress in eukaryotes. RNA 14(10):2095-103

Abstract: Recent results have identified a diversity of small RNAs in a wide range of organisms. In this work, we demonstrate that Saccharomyces cerevisiae contains a small RNA population consisting primarily of tRNA halves and rRNA fragments. Both 5' and 3' fragments of tRNAs are detectable by Northern blot analysis, suggesting a process of endonucleolytic cleavage. tRNA and rRNA fragment production in yeast is most pronounced during oxidative stress conditions, especially during entry into stationary phase. Similar tRNA fragments are also observed in human cell lines and in plants during oxidative stress. These results demonstrate that tRNA cleavage is a conserved aspect of the response to oxidative stress.

Status: Published Type: Journal Article PubMed ID: 18719243

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
CCA1 CDC65 EMT1 EMT2 EMT3 EMT4 EMT5 HSX1 HTS1 IMT1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cell Growth and Metabolism yg ball
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Topics Genes linked to topics (#11 - 20 )
IMT2 IMT3 IMT4 PAP2 RRP6 SKI2 SKI7 SOE1 SUF1 SUF10
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Topics Genes linked to topics (#21 - 30 )
SUF11 SUF16 SUF17 SUF2 SUF20 SUF3 SUF4 SUF5 SUF6 SUF7
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Topics Genes linked to topics (#31 - 40 )
SUF8 SUF9 SUP11 SUP16 SUP17 SUP19 SUP2 SUP3 SUP4 SUP5
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#41 - 50 )
SUP51 SUP53 SUP54 SUP56 SUP6 SUP61 SUP7 SUP8 tA(AGC)D tA(AGC)F
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Topics Genes linked to topics (#51 - 60 )
tA(AGC)G tA(AGC)H tA(AGC)J tA(AGC)K1 tA(AGC)K2 tA(AGC)L tA(AGC)M1 tA(AGC)M2 tA(AGC)P tA(UGC)A
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Topics Genes linked to topics (#61 - 70 )
tA(UGC)E tA(UGC)G tA(UGC)L tA(UGC)O tA(UGC)Q tC(GCA)B tC(GCA)G tC(GCA)P1 tC(GCA)P2 tC(GCA)Q
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Topics Genes linked to topics (#71 - 80 )
tD(GUC)B tD(GUC)D tD(GUC)G1 tD(GUC)G2 tD(GUC)I1 tD(GUC)I2 tD(GUC)J1 tD(GUC)J2 tD(GUC)J3 tD(GUC)J4
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#81 - 90 )
tD(GUC)K tD(GUC)L1 tD(GUC)L2 tD(GUC)M tD(GUC)N tD(GUC)O tD(GUC)Q tE(CUC)D tE(CUC)I tE(UUC)B
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#91 - 100 )
tE(UUC)C tE(UUC)E1 tE(UUC)E2 tE(UUC)E3 tE(UUC)G2 tE(UUC)G3 tE(UUC)I tE(UUC)J tE(UUC)K tE(UUC)L
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#101 - 110 )
tE(UUC)M tE(UUC)P tE(UUC)Q tF(GAA)B tF(GAA)D tF(GAA)F tF(GAA)G tF(GAA)H1 tF(GAA)H2 tF(GAA)M
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#111 - 120 )
tF(GAA)N tF(GAA)P1 tF(GAA)P2 tF(GAA)Q tG(GCC)B tG(GCC)D1 tG(GCC)D2 tG(GCC)E tG(GCC)F2 tG(GCC)G1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#121 - 130 )
tG(GCC)G2 tG(GCC)J1 tG(GCC)J2 tG(GCC)M tG(GCC)O1 tG(GCC)P1 tG(GCC)P2 tG(UCC)Q tH(GUG)E1 tH(GUG)E2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#131 - 140 )
tH(GUG)G1 tH(GUG)G2 tH(GUG)H tH(GUG)K tH(GUG)M tH(GUG)Q tI(AAU)B tI(AAU)D tI(AAU)E1 tI(AAU)E2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#141 - 150 )
tI(AAU)G tI(AAU)I1 tI(AAU)I2 tI(AAU)L1 tI(AAU)L2 tI(AAU)N1 tI(AAU)N2 tI(AAU)P1 tI(AAU)P2 tI(GAU)Q
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#151 - 160 )
tI(UAU)D tI(UAU)L tK(CUU)C tK(CUU)D1 tK(CUU)D2 tK(CUU)E1 tK(CUU)E2 tK(CUU)F tK(CUU)G1 tK(CUU)G2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#161 - 170 )
tK(CUU)G3 tK(CUU)I tK(CUU)J tK(CUU)K tK(CUU)M tK(CUU)P tK(UUU)D tK(UUU)G1 tK(UUU)G2 tK(UUU)K
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#171 - 180 )
tK(UUU)L tK(UUU)O tK(UUU)P tK(UUU)Q tL(CAA)D tL(CAA)G1 tL(CAA)G3 tL(CAA)K tL(CAA)L tL(CAA)M
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#181 - 190 )
tL(CAA)N tL(GAG)G tL(UAA)B1 tL(UAA)B2 tL(UAA)D tL(UAA)K tL(UAA)L tL(UAA)N tL(UAA)Q tL(UAG)J
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#191 - 200 )
tL(UAG)L1 tL(UAG)L2 tM(CAU)C tM(CAU)Q1 tM(CAU)Q2 tN(GUU)C tN(GUU)F tN(GUU)G tN(GUU)K tN(GUU)L
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#201 - 210 )
tN(GUU)N1 tN(GUU)N2 tN(GUU)O1 tN(GUU)O2 tN(GUU)P tN(GUU)Q tP(UGG)L tP(UGG)N1 tP(UGG)N2 tP(UGG)O1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#211 - 220 )
tP(UGG)O3 tP(UGG)Q tQ(UUG)B tQ(UUG)C tQ(UUG)D1 tQ(UUG)D2 tQ(UUG)D3 tQ(UUG)E1 tQ(UUG)E2 tQ(UUG)H
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#221 - 230 )
tQ(UUG)L tQ(UUG)Q tR(ACG)D tR(ACG)E tR(ACG)J tR(ACG)K tR(ACG)L tR(ACG)O tR(ACG)Q2 tR(UCU)B
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#231 - 240 )
tR(UCU)D tR(UCU)E tR(UCU)G1 tR(UCU)G2 tR(UCU)G3 tR(UCU)J1 tR(UCU)J2 tR(UCU)K tR(UCU)M1 tR(UCU)M2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#241 - 250 )
tR(UCU)Q1 TRM8 TRM82 TRN1 TRR4 TRT2 tS(AGA)A tS(AGA)B tS(AGA)D1 tS(AGA)D2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Strains/Constructs blue ball blue ball

Topics Genes linked to topics (#251 - 260 )
tS(AGA)D3 tS(AGA)E tS(AGA)G tS(AGA)H tS(AGA)J tS(AGA)L tS(AGA)M tS(GCU)F tS(GCU)O tS(GCU)Q1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#261 - 270 )
tS(UGA)Q2 tT(AGU)B tT(AGU)C tT(AGU)D tT(AGU)H tT(AGU)I1 tT(AGU)I2 tT(AGU)J tT(AGU)N1 tT(AGU)N2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Regulation of blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#271 - 280 )
tT(AGU)O1 tT(AGU)O2 tT(UAG)Q2 tT(UGU)G1 tT(UGU)G2 tT(UGU)H tT(UGU)P tT(UGU)Q1 tV(AAC)E1 tV(AAC)E2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#281 - 290 )
tV(AAC)G1 tV(AAC)G2 tV(AAC)G3 tV(AAC)H tV(AAC)J tV(AAC)K1 tV(AAC)K2 tV(AAC)L tV(AAC)M1 tV(AAC)M2
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Topics Genes linked to topics (#291 - 300 )
tV(AAC)M3 tV(AAC)O tV(CAC)D tV(CAC)H tV(UAC)B tV(UAC)D tV(UAC)Q tW(CCA)G1 tW(CCA)G2 tW(CCA)J
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Topics Genes linked to topics (#301 - 308 )
tW(CCA)K tW(CCA)M tW(CCA)P tW(UCA)Q tX(XXX)D tX(XXX)L tY(GUA)Q XRN1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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