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Lin YY, et al.  (2008) A comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation. Genes Dev 22(15):2062-74

Abstract: Histone acetylation and deacetylation are among the principal mechanisms by which chromatin is regulated during transcription, DNA silencing, and DNA repair. We analyzed patterns of genetic interactions uncovered during comprehensive genome-wide analyses in yeast to probe how histone acetyltransferase (HAT) and histone deacetylase (HDAC) protein complexes interact. The genetic interaction data unveil an underappreciated role of HDACs in maintaining cellular viability, and led us to show that deacetylation of the histone variant Htz1p at Lys 14 is mediated by Hda1p. Studies of the essential nucleosome acetyltransferase of H4 (NuA4) revealed acetylation-dependent protein stabilization of Yng2p, a potential nonhistone substrate of NuA4 and Rpd3C, and led to a new functional organization model for this critical complex. We also found that DNA double-stranded breaks (DSBs) result in local recruitment of the NuA4 complex, followed by an elaborate NuA4 remodeling process concomitant with Rpd3p recruitment and histone deacetylation. These new characterizations of the HDA and NuA4 complexes demonstrate how systematic analyses of genetic interactions may help illuminate the mechanisms of intricate cellular processes.

Status: Published Type: Journal Article PubMed ID: 18676811

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Topics Topics not linked to Genes Genes linked to topics
EAF1 EPL1 ESA1 GCN5 HDA1 HTZ1 RPD3 YNG2
Additional Literature blue ball blue ball
Cellular Location blue ball blue ball blue ball blue ball
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Large-scale genetic interaction yg ball
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Protein Processing/Modification/Regulation blue ball blue ball
Protein Sequence Features blue ball
Protein-Nucleic Acid Interactions blue ball blue ball blue ball blue ball
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