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Maxwell PH and Curcio MJ  (2008) Incorporation of Y'-Ty1 cDNA Destabilizes Telomeres in Saccharomyces cerevisiae Telomerase-Negative Mutants. Genetics 179(4):2313-7

Abstract: Ty1 retrotransposons in Saccharomyces cerevisiae are activated in response to telomere erosion. Ty1-dependent reverse transcription of mRNA from subtelomeric Y' repeats generates chimeric Y'-Ty1 cDNA. Here, we show that Y'-Ty1 cDNA is incorporated at eroding telomeres in the absence of telomerase. Telomeric incorporation of Y'-Ty1 cDNA promotes genome rearrangements.

Status: Published Type: Journal Article PubMed ID: 18660531

Topics addressed in this paper

Number of different genes curated to this paper: 47

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Topics Genes linked to topics (#1 - 10 )
RAD51 RAD52 TEL02L-YP TEL04R-YP TEL05L-YP TEL05R-YP TEL06L-YP TEL07R-YP TEL08L-YP TEL08R-YP
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Topics Genes linked to topics (#11 - 20 )
TEL09L-YP TEL10L-YP TEL13L-YP TEL14L-YP TEL15R-YP TEL16L-YP TEL16R-YP TLC1 YBLWTy1-1 YBRWTy1-2
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Topics Genes linked to topics (#21 - 30 )
YDRCTy1-1 YDRCTy1-2 YDRWTy1-4 YDRWTy1-5 YERCTy1-1 YERCTy1-2 YGRCTy1-2 YGRCTy1-3 YGRWTy1-1 YHRCTy1-1
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Topics Genes linked to topics (#31 - 40 )
YJRWTy1-1 YJRWTy1-2 YLRCTy1-1 YLRWTy1-2 YLRWTy1-3 YMLWTy1-1 YMLWTy1-2 YMRCTy1-3 YMRCTy1-4 YNLCTy1-1
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Topics Genes linked to topics (#41 - 47 )
YNLWTy1-2 YOLWTy1-1 YORWTy1-2 YPLWTy1-1 YPRCTy1-2 YPRCTy1-4 YPRWTy1-3
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