Caplan AJ, et al. (2007) Multiple kinases and system robustness: a link between Cdc37 and genome integrity. Cell Cycle 6(24):3145-7
Abstract: We identified 38 genes as having a genetic interaction with a mutant form of the kinase specific chaperone, Cdc37, using a genome-wide synthetic screening approach. The identified genes included a sub-network of highly interacting genes enriched for functions in genome integrity and comprising multiple components of several discrete molecular machines. A network analysis approach related these machines to a small group of cell cycle checkpoint kinases.
|Status: Published||Type: Letter | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't||PubMed ID: 18075309|
Topics addressed in this paper
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|Large-scale genetic interaction|
|Protein Sequence Features|