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Cheraiti N, et al.  (2008) Acetaldehyde addition throughout the growth phase alleviates the phenotypic effect of zinc deficiency in Saccharomyces cerevisiae. Appl Microbiol Biotechnol 77(5):1093-1109

Abstract: During experiments to determine the effects of exogenously added acetaldehyde on pure cultures of various yeast strains, we discovered that an early acetaldehyde perfusion during the growth phase allowed several yeasts to partially overcome the phenotypic effects of zinc depletion during alcoholic fermentation. We, therefore, performed genome-wide expression and proteomic analysis on an industrial Saccharomyces cerevisiae yeast strain (VL1) growing in zinc-replete or zinc-depleted conditions in the presence of perfused acetaldehyde to identify molecular markers of this effect. Zinc depletion severely affects ethanol production and therefore nicotinamide adenine dinucleotide (NAD) regeneration, although we observed partial compensation by the upregulation of the poorly efficient Fe-dependent Adh4p in our conditions. A coordinate metabolic response was indeed observed in response to the early acetaldehyde perfusion, and particularly of the lower part of glycolysis, leading to the cellular replenishment of NAD cofactor. These various findings suggest that acetaldehyde exchange between strains may inhibit the growth of some yeast strains while encouraging the growth of others. This phenomenon could be particularly important for understanding the ecology of colonization of complex fermentation media by S. cerevisiae after elimination of non-Saccharomyces yeasts.

Status: Published Type: Journal Article PubMed ID: 17938904

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Number of different genes curated to this paper: 152

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AAD14 AAD15 AAD16 AAD3 AAD4 AAH1 ACH1 ADH1 ADH4 ALD3
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Genomic expression study yg ball
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Topics Genes linked to topics (#11 - 20 )
ALO1 APE1 ARG3 ARO1 ASC1 ATG33 ATP2 BAP2 BDH1 CAN1
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Topics Genes linked to topics (#21 - 30 )
CBF1 CDC19 CDS1 CPS1 CPT1 CTA1 CTR1 CTT1 DAK1 DAL5
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Topics Genes linked to topics (#31 - 40 )
DAL80 DIP5 DMC1 DON1 DPP1 DUG1 DUR1,2 ENO1 ENO2 EPT1
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Topics Genes linked to topics (#41 - 50 )
ERR2 FAS1 FAS2 FBA1 FMP40 GAP1 GAS4 GIT1 GLC3 GLK1
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GND1 GOR1 GPH1 GRE1 GRE2 HNM1 HSP12 HSP26 HSP30 INO1
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Topics Genes linked to topics (#61 - 70 )
ITR1 IZH2 LIA1 LSC1 MCM7 MCR1 MDH1 MDH3 MEF2 MNT2
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Topics Genes linked to topics (#71 - 80 )
MOT3 MUP1 OLE1 OM45 OPI3 PAU1 PAU17 PAU2 PAU3 PAU4
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Topics Genes linked to topics (#81 - 90 )
PAU5 PAU7 PAU8 PAU9 PGK1 PMA1 PMA2 PMP2 PTR2 PUT1
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Topics Genes linked to topics (#91 - 100 )
PUT2 RLF2 RNR2 RPL12A RPL30 RPL31A RPL4A RPL6B RPL9B RPS12
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Topics Genes linked to topics (#101 - 110 )
RPS13 RPS14B RPS16B RPS24A RPS25A RPS7B RTC4 SAM2 SIT1 SNF2
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Topics Genes linked to topics (#111 - 120 )
SSA2 SSA3 SSB1 STL1 STU2 TAL1 TAT1 TDH1 TDH2 TDH3
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Topics Genes linked to topics (#121 - 130 )
THI11 THI12 THI13 THI4 THI5 THI72 TIR3 TIR4 TKL2 TMT1
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Topics Genes linked to topics (#131 - 140 )
TPN1 TPS1 TPS2 TRX1 TSA1 TSA2 TYW1 UBI4 VHT1 VMA1
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Topics Genes linked to topics (#141 - 150 )
YDL218W YEL073C YHR033W YLL053C YNR068C YNR071C YPL276W ZIP1 ZPS1 ZRT1
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Topics Genes linked to topics (#151 - 152 )
ZRT2 ZRT3
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