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Rowicka M, et al.  (2007) High-resolution timing of cell cycle-regulated gene expression. Proc Natl Acad Sci U S A 104(43):16892-7

Abstract: The eukaryotic cell division cycle depends on an intricate sequence of transcriptional events. Using an algorithm based on maximum-entropy deconvolution, and expression data from a highly synchronized yeast culture, we have timed the peaks of expression of transcriptionally regulated cell cycle genes to an accuracy of 2 min ( approximately 1% of the cell cycle time). The set of 1,129 cell cycle-regulated genes was identified by a comprehensive analysis encompassing all available cell cycle yeast data sets. Our results reveal distinct subphases of the cell cycle undetectable by morphological observation, as well as the precise timeline of macromolecular complex assembly during key cell cycle events.

Status: Published Type: Journal Article PubMed ID: 17827275

Topics addressed in this paper

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
BNI4 BUD13 CDC11 CDC12 CDC28 CDC3 CLB1 CLN2 CLN3 FKS1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cell Cycle Phase Involved blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#11 - 20 )
GAS1 GAS5 GIC2 HHF2 HHO1 HHT1 HHT2 HTA2 HTB1 HTB2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cell Cycle Phase Involved blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Transcription blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 30 )
HTZ1 MCM3 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PCL9 PEA2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cell Cycle Phase Involved blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 34 )
RAX1 RSR1 SWE1 SWI5
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