Wickner RB, et al. (2007) Prions of fungi: inherited structures and biological roles. Nat Rev Microbiol 5(8):611-8
Abstract: The term 'prion' means an infectious protein that does not need an accompanying nucleic acid. There are six fungal prions, including four self-propagating amyloids and two enzymes that are necessary to activate their inactive precursors. Here we explore the scope of the prion phenomenon, the biological and evolutionary roles of prions, the structural basis of the amyloid prions and the prominent role of chaperones (proteins that affect the folding of other proteins) and other cellular components in prion generation and propagation.
|Status: Published||Type: Journal Article | Research Support, N.I.H., Intramural | Review||PubMed ID: 17632572|
Topics addressed in this paper
Number of different genes curated to this paper: 4
- To go to the Locus page for a gene, click on the gene name.