Karnitz LM and Felts SJ (2007) Cdc37 regulation of the kinome: when to hold 'em and when to fold 'em. Sci STKE 2007(385):pe22
Abstract: Although massive genome sequencing efforts have identified the protein kinases encoded by several eukaryotic genomes and proteomic analyses have begun to determine the kinases expressed in a cell, there is still much to learn about the additional cellular events that shape eukaryotic kinomes. Large-scale analyses in Saccharomyces cerevisiae have indicated that a relatively small subset of kinases requires chaperoning by heat shock protein 90 (Hsp90). However, new evidence suggests that most kinases do require chaperoning and, furthermore, that Cdc37, a chaperone that has Hsp90-dependent and -independent functions, serves as the chaperone for a large portion of the yeast kinome.
|Status: Published||Type: Journal Article||PubMed ID: 17488976|
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