Klose RJ, et al. (2007) Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of an H3K9 methylation system in Saccharomyces cerevisiae? Mol Cell Biol 27(11):3951-61
Abstract: Histone methylation is an important post-translational modification that contributes to chromatin based processes including transcriptional regulation, DNA repair, and epigenetic inheritance. In budding yeast, Saccharomyces cerevisiae, histone lysine methylation occurs on histone H3 lysine 4, 36 and 79 and its deposition is mainly coupled to transcription. Until recently, histone methylation was considered irreversible but the identification of histone demethylase enzymes has revealed that this modification can be dynamically regulated. In budding yeast there are five proteins which contain the JmjC domain, a signature motif found in a large family of histone demethylases spanning many organisms. One JmjC domain-containing protein in budding yeast, Jhd1, has recently been identified as a histone demethylase which targets H3K36 modified in the di and mono-methyl state. Here we identify a second JmjC domain-containing histone demethylase, Rph1, which can specifically demethylate H3K36 tri and di-methyl modification states. Surprisingly, Rph1 can remove H3K9 methylation, a histone modification not found in budding yeast chromatin. The capacity of Rph1 to demethylate H3K9 provides the first indication that S. cerevisiae may have once encoded an H3K9 methylation system and suggests that Rph1 is a functional vestige of this modification system.
|Status: Published||Type: Journal Article||PubMed ID: 17371840|
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