Bettendorff L, et al. (2007) Discovery of a natural thiamine adenine nucleotide. Nat Chem Biol 3(4):211-2
Abstract: Several important cofactors are adenine nucleotides with a vitamin as the catalytic moiety. Here, we report the discovery of the first adenine nucleotide containing vitamin B1: adenosine thiamine triphosphate (AThTP, 1), or thiaminylated ATP. We discovered AThTP in Escherichia coli and found that it accumulates specifically in response to carbon starvation, thereby acting as a signal rather than a cofactor. We detected smaller amounts in yeast and in plant and animal tissues.
|Status: Published||Type: Journal Article||PubMed ID: 17334376|
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