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Suzuki K, et al.  (2007) Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes Cells 12(2):209-18

Abstract: Autophagy is a bulk degradation process that is conserved in eukaryotic cells and functions in the turnover of cytoplasmic materials and organelles. When eukaryotic cells face nutrient starvation, the autophagosome, a double-membraned organelle, is generated from the pre-autophagosomal structure (PAS). In the yeast Saccharomyces cerevisiae, 16 ATG (autophagy-related) genes are essential for autophagosome formation. Most of the Atg proteins are involved in the PAS, leading to autophagosome production. However, the mechanism of PAS organization remains to be elucidated. Here, we performed a systematic and quantitative analysis by fluorescence microscopy to develop a hierarchy map of Atg proteins involved in PAS organization. This analysis suggests that Atg17p is the most basic protein in PAS organization: when it is specifically targeted to the plasma membrane, other Atg proteins are recruited to that location, suggesting that Atg17p acts as a scaffold protein to organize Atg proteins to the PAS.

Status: Published Type: Journal Article PubMed ID: 17295840

Topics addressed in this paper

Number of different genes curated to this paper: 17

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Topics Genes linked to topics (#1 - 10 )
ATG1 ATG10 ATG11 ATG12 ATG13 ATG14 ATG16 ATG17 ATG18 ATG2
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Topics Genes linked to topics (#11 - 17 )
ATG3 ATG4 ATG5 ATG7 ATG8 ATG9 VPS30
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