Serber Z and Ferrell JE Jr (2007) Tuning bulk electrostatics to regulate protein function. Cell 128(3):441-4
Abstract: Cyclin-dependent kinase activation can prevent yeast cells from responding to mating pheromone. now show that this block arises from the multisite phosphorylation of Ste5. This provides a beautiful example of how phosphorylation can produce decisive changes in protein function through bulk electrostatics, without the necessity of intricate conformational changes.
|Status: Published||Type: Journal Article||PubMed ID: 17289565|
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