Xie J and Schultz PG (2006) A chemical toolkit for proteins--an expanded genetic code. Nat Rev Mol Cell Biol 7(10):775-82
Abstract: Recently, a method to encode unnatural amino acids with diverse physicochemical and biological properties genetically in bacteria, yeast and mammalian cells was developed. Over 30 unnatural amino acids have been co-translationally incorporated into proteins with high fidelity and efficiency using a unique codon and corresponding transfer-RNA:aminoacyl-tRNA-synthetase pair. This provides a powerful tool for exploring protein structure and function in vitro and in vivo, and for generating proteins with new or enhanced properties.
|Status: Published||Type: Journal Article||PubMed ID: 16926858|
Topics addressed in this paper
- To go to the Locus page for a gene, click on the gene name.
|Topics||Topics not linked to Genes|
|Techniques and Reagents|