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Sikder D, et al.  (2006) Widespread, but non-identical, association of proteasomal 19 and 20 S proteins with yeast chromatin. J Biol Chem 281(37):27346-55

Abstract: It has recently become clear that various aspects of nucleic acid metabolism and the ubiquitin-proteasome pathway intersect in several direct and important ways. To begin to assess the scope of some of these activities is the yeast Saccharomyces cerevisiae, we have assessed the physical and functional association of proteasomal proteins from both the 20S core and 19S regulatory particles with approximately 6400 yeast genes. Genome-wide chromatin immunoprecipitation analyses reveal that proteasome substituents are associated with the majority of yeast genes. Many of these associations correlate strongly with expression levels and the presence of RNA polymerase II. While the data support the presence of the intact 26S proteasome on most genes, several hundred yeast genes cross-link to either the 20S or 19S complex, but not both, consistent with some degree of independent function for the proteasomal sub-complexes.

Status: Published Type: Journal Article PubMed ID: 16837462

Topics addressed in this paper

Number of different genes curated to this paper: 58

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ACH1 ADE1 ADE4 ADE8 ADH6 AGE2 ARN1 ATG10 BAP3 BUL1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Genomic expression study yg ball
Omics yg ball
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Topics Genes linked to topics (#11 - 20 )
COR1 COX1 CYB2 DLD1 ERV46 GAL1 GAL10 GAL3 GAL7 GCV1
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Protein-Nucleic Acid Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#21 - 30 )
GCY1 GLN1 GSC2 HIS4 HIS7 HKR1 HOL1 HXT1 HXT3 LEU2
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Topics Genes linked to topics (#31 - 40 )
MLF3 MLP1 MTD1 MTH1 MUD2 OM14 PCL10 PGM2 PRE1 RAD16
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Cellular Location blue ball
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Topics Genes linked to topics (#41 - 50 )
RAD59 RAD7 RPA190 RPB3 RPT4 RPT6 SEC62 SPB1 SRN2 SVS1
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Topics Genes linked to topics (#51 - 58 )
TAF13 TAF9 TDA6 TKL2 TUB2 YEL057C YFL052W YPS3
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Protein-Nucleic Acid Interactions blue ball blue ball blue ball blue ball blue ball blue ball
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