Raisner RM and Madhani HD (2006) Patterning chromatin: form and function for H2A.Z variant nucleosomes. Curr Opin Genet Dev 16(2):119-24
Abstract: Although many histone variants are specific to higher eukaryotes, the H2A variant H2A.Z has been conserved during eukaryotic evolution. Genetic studies have demonstrated roles for H2A.Z in antagonizing gene-silencing, chromosome stability and gene activation. Biochemical work has identified a conserved chromatin-remodeling complex responsible for H2A.Z deposition. Recent studies have shown that two H2A.Z nucleosomes flank a nucleosome-free region containing the transcription initiation site in promoters of both active and inactive genes in Saccharomyces cerevisiae. This chromatin pattern is generated through the action of a DNA deposition signal and a specific pattern of histone tail acetylation.
|Status: Published||Type: Journal Article||PubMed ID: 16503125|
Topics addressed in this paper
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