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Titz B, et al.  (2006) Transcriptional activators in yeast. Nucleic Acids Res 34(3):955-67

Abstract: Eukaryotic transcription activation domains (ADs) are not well defined on the proteome scale. We systematicallly tested approximately 6000 yeast proteins for transcriptional activity using a yeast one-hybrid system and identified 451 transcriptional activators. We then determined their transcription activation strength using fusions to the Gal4 DNA-binding domain and a His3 reporter gene which contained a promoter with a Gal4-binding site. Among the 132 strongest activators 32 are known transcription factors while another 35 have no known function. Although zinc fingers, helix-loop-helix domains and several other domains are highly overrepresented among the activators, only few contain characterized ADs. We also found some striking correlations: the stronger the activation activity, the more acidic, glutamine-rich, proline-rich or asparagine-rich the activators were. About 29% of the activators have been found previously to specifically interact with the transcription machinery, while 10% are known to be components of transcription regulatory complexes. Based on their transcriptional activity, localization and interaction patterns, at least six previously uncharacterized proteins are suggested to be bona fide transcriptional regulators (namely YFL049W, YJR070C, YDR520C, YGL066W/Sgf73, YKR064W and YCR082W/Ahc2).

Status: Published Type: Journal Article PubMed ID: 16464826

Topics addressed in this paper

Number of different genes curated to this paper: 134

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ACA1 ACE2 ACF2 ADR1 AHC2 AIR1 AOS1 APC4 APL2 ASM4
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Topics Genes linked to topics (#11 - 20 )
ATC1 BCK2 BFR2 BSC5 CAK1 CHA4 COG1 COG2 CRF1 CRZ1
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Topics Genes linked to topics (#21 - 30 )
CSE2 CSM3 CUP2 DYN3 ECM22 EFM2 ENT1 FAF1 FCP1 GAC1
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Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 40 )
GAL11 GLN3 GMC2 GPN2 GYP1 HAA1 HAP4 HCR1 HDA3 HRQ1
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Topics Genes linked to topics (#41 - 50 )
HSF1 ICY1 ICY2 IDS2 IKI1 IME1 ISF1 JHD1 JHD2 KXD1
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Topics Genes linked to topics (#51 - 60 )
LIA1 LTV1 MBR1 MCD4 MED4 MED8 MET4 MIC14 MPE1 MRS6
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Topics Genes linked to topics (#61 - 70 )
MSA1 MSA2 MSB4 MSN2 MVP1 NAM7 NAP1 NCA3 NNK1 NNT1
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Topics Genes linked to topics (#71 - 80 )
NSL1 NUP100 OAF3 PAT1 PCL6 PDC2 PEX18 PEX19 PFK27 PHO4
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Topics Genes linked to topics (#81 - 90 )
PPG1 PUF3 PUP2 PUT3 REC114 RIM15 RLM1 ROX3 RPA12 RPB3
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Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein Physical Properties blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#91 - 100 )
RPI1 RPP1A RSF1 RSP5 RTG1 SCD5 SCH9 SGF73 SIN4 SIW14
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Topics Genes linked to topics (#101 - 110 )
SLA1 SLD5 SLX4 SNF2 SPT21 SSN2 STE5 SWA2 SWI3 SWI5
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Topics Genes linked to topics (#111 - 120 )
SWM1 SWP82 SWT1 SYH1 SYN8 TIM23 TOA1 TRM7 UBP3 UBX5
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Topics Genes linked to topics (#121 - 130 )
UPC2 URC2 UTP30 VPS53 YAP1802 YBL081W YGL036W YGR130C YHL012W YJL181W
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Topics Genes linked to topics (#131 - 134 )
YML037C YMR181C YMR295C YPL229W
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Primary Literature blue ball
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