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Sopko R, et al.  (2006) Mapping pathways and phenotypes by systematic gene overexpression. Mol Cell 21(3):319-30

Abstract: Many disease states result from gene overexpression, often in a specific genetic context. To explore gene overexpression phenotypes systematically, we assembled an array of 5280 yeast strains, each containing an inducible copy of an S. cerevisiae gene, covering >80% of the genome. Approximately 15% of the overexpressed genes (769) reduced growth rate. This gene set was enriched for cell cycle-regulated genes, signaling molecules, and transcription factors. Overexpression of most toxic genes resulted in phenotypes different from known deletion mutant phenotypes, suggesting that overexpression phenotypes usually reflect a specific regulatory imbalance rather than disruption of protein complex stoichiometry. Global overexpression effects were also assayed in the context of a cyclin-dependent kinase mutant (pho85Delta). The resultant gene set was enriched for Pho85p targets and identified the yeast calcineurin-responsive transcription factor Crz1p as a substrate. Large-scale application of this approach should provide a strategy for identifying target molecules regulated by specific signaling pathways.

Status: Published Type: Journal Article PubMed ID: 16455487

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AAC3 ABF2 ACK1 ADY4 AIM19 ALK2 AMN1 ANT1 ASM4 BBP1
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BET1 BIK1 BIM1 BOI1 BRN1 BSP1 BTN2 BUD14 BUD3 BUD8
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CCZ1 CDC11 CDC13 CDC48 CDC5 CDC53 CLB2 CLB3 CLB4 CLB5
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Topics Genes linked to topics (#31 - 40 )
CNM67 COS111 COX20 CRZ1 CTH1 CTR1 DBF20 DMA1 DSK2 ECM22
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Topics Genes linked to topics (#41 - 50 )
ENT2 ERG6 EXO84 FAR1 FCP1 FIS1 FLX1 FRS1 FSF1 GAR1
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GDS1 GEA2 GIC1 GIC2 GIP4 GIS1 GYP8 GZF3 HAC1 HHF1
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Topics Genes linked to topics (#61 - 70 )
HHT2 HMLALPHA2 HMS1 HRT3 HSE1 HSL1 HTA1 HTA2 HTB1 HTZ1
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HXT10 ICY1 INO2 IQG1 ITR1 JJJ2 KAR1 KEL1 KIN3 KIN4
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Topics Genes linked to topics (#81 - 90 )
KIP2 LAS17 LRE1 MATALPHA2 MBP1 MCD1 MCM10 MDM30 MET4 MIG1
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Topics Genes linked to topics (#91 - 100 )
MPC2 MPS1 MPS2 MSA1 MSB4 NNK1 NPR3 NUP1 ODC1 PDE2
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Topics Genes linked to topics (#101 - 110 )
PDS1 PEX2 PHO4 PHO80 PHO81 PHO85 PIG1 PML1 POL32 PPH21
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Topics Genes linked to topics (#111 - 120 )
PPH22 PRM1 PTR2 PUF4 PUT3 RED1 RET1 RGR1 RIM4 RPS7A
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Topics Genes linked to topics (#121 - 130 )
RRM3 RSA1 SAS10 SCM4 SCO2 SGS1 SGV1 SHE1 SHS1 SKN7
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Topics Genes linked to topics (#131 - 140 )
SKP2 SLG1 SLI15 SLM2 SNC1 SNF7 SNQ2 SOK2 SOL4 SPC29
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Topics Genes linked to topics (#141 - 150 )
SPC42 SPC98 SPO13 SPT23 SSK1 STE4 SWI4 TID3 TOM22 TOM5
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Topics Genes linked to topics (#151 - 160 )
TOM7 TPK1 TPK2 TSR2 UBP10 UPC2 VAB2 WHI4 WSC2 XBP1
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Topics Genes linked to topics (#161 - 170 )
YAP1801 YBP1 YDL129W YDL183C YDL186W YDR249C YEL045C YHP1 YMC1 YMR052C-A
Mutants/Phenotypes blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#171 - 176 )
YPK1 YPL279C YPR011C YPT11 YRO2 YSH1
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