Andrews CA, et al. (2005) Evidence that the yeast spindle assembly checkpoint has a target other than the anaphase promoting complex. Cell Cycle 4(11):1555-7
Abstract: The spindle assembly checkpoint monitors biorientation of chromosomes on the metaphase spindle and inhibits the Anaphase Promoting Complex (APC) specificity factor Cdc20. If APC-Cdc20 is the sole target of the spindle checkpoint, then cells lacking APC and its targets, B-type cyclin and securin, would lack spindle checkpoint function. We tested this hypothesis in yeast cells that are APC-null. Surprisingly, we find that such yeast cells are able to activate the spindle assembly checkpoint, delaying cell cycle progression in G(2)/M phase. These data suggest that the spindle checkpoint has a non-APC target that can restrain anaphase onset.
|Status: Published||Type: Journal Article||PubMed ID: 16258265|
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