SGD Paper 
Page Contents:
Andrews CA, et al. (2005) Evidence that the yeast spindle assembly checkpoint has a target other than the anaphase promoting complex. Cell Cycle 4(11):1555-7
Abstract: The spindle assembly checkpoint monitors biorientation of chromosomes on the metaphase spindle and inhibits the Anaphase Promoting Complex (APC) specificity factor Cdc20. If APC-Cdc20 is the sole target of the spindle checkpoint, then cells lacking APC and its targets, B-type cyclin and securin, would lack spindle checkpoint function. We tested this hypothesis in yeast cells that are APC-null. Surprisingly, we find that such yeast cells are able to activate the spindle assembly checkpoint, delaying cell cycle progression in G(2)/M phase. These data suggest that the spindle checkpoint has a non-APC target that can restrain anaphase onset.
| Status: Published | Type: Journal Article | PubMed ID: 16258265 |
Topics addressed in this paper
Number of different genes curated to this paper: 7
- To find other papers on a gene and topic, click on the colored ball in the appropriate box.
- displays other papers with information about that topic for that gene.
- displays other papers in SGD that are associated with that topic.
The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
- To go to the Locus page for a gene, click on the gene name.
Page Contents:
