SGD Paper 
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Nikawa J and Yamashita S (1992) IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae. Mol Microbiol 6(11):1441-6
Abstract: A novel gene, IRE1, of Saccharomyces cerevisiae was cloned through genetic complementation of a myoinositol auxotrophic mutant. The predicted amino acid sequence indicated that IRE1 encodes a protein of 126983 Da with two highly hydrophobic regions, probably a signal sequence and a membrane-spanning region. The carboxy-terminal region of IRE1 showed close sequence similarity to the catalytic domains of protein kinases. Disruption of the IRE1 locus caused myo-inositol auxotrophy. The IRE1 product is very likely a protein kinase required for myo-inositol synthesis.
| Status: Published | Type: Journal Article | PubMed ID: 1625574 |
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| Topics | Genes linked to topics |
|---|---|
| IRE1 | |
| DNA/RNA Sequence Features |  |
| Function/Process | |
| Mutants/Phenotypes | |
| Primary Literature | |
| Protein Sequence Features | |
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